Description
FORMULA
Furosemide………………2 g
Formulation agents q.s.
DESCRIPTION
Furosemide is a diuretic that works by blocking the Na + K + 2Cl – cotransporter in the thick ascending limb of Henle’s loop. This causes a decline in these ions’ reuptake and a decrease of interstitial hypertonicity, which trigger the diuretic effect.
Furosemide also acts on vascular tone by causing dilation of venous vessels, increasing elasticity and systemic venous capacitance. The result is a decrease of central venous blood pressure, pulmonary arterial blood pressure, and a reduction of the afterload on the left ventricle, which enhances stroke volume and cardiac output, and leads to secondary decreases in ventricular preload and venous pressures.
USAGE
Treatment of dilated cardiomyopathy, pulmonary edema, mammary edema, and other conditions Treatment of hypercalciuric
nephrolithiasis, elevated uremia, as adjuvant therapy for hyperkalemia, and occasionally as an antihypertensive agent.
TARGET SPECIES
Cats and dogs
ADMINISTRATION ROUTE
Oral.
DOSAGE
Cats and dogs: 1-4 drops per kilo (equivalent to 1-4 mg/kg bw). Administer every 8, 12 or 24 h, depending on the severity of the
symptoms, and according to the directions of the veterinarian.
CONTRAINDICATIONS
Contraindicated in animals with diabetes mellitus, anuria, or severe kidney or liver failure, as the possibility of furosemide causing dehydration or electrolyte unbalance could worsen the condition. Pancreatitis, conditions that could cause hypokalemia like diarrhea, nephropathy, liver cirrhosis and ascites.
Ototoxicity presents more frequently if furosemide is administered IV; this effect is less common when administered orally.
Furosemide should be used during pregnancy only if the benefits of the treatment justify potential risks for the fetus.
WARNINGS
Aged animals can be more sensitive to the hypotensive and/or diuretic effects of the active ingredient.
STORAGE
Keep between 5 and 30oC, in a dry place, away from sunlight.
HOW SUPPLIED
Droppers containing 20 mL
